Atherogenic Index of Plasma (AIP)

What is the Atherogenic Index of Plasma (AIP)?

The Atherogenic Index of Plasma (AIP) is a logarithmically transformed ratio of Triglycerides to HDL-Cholesterol. It is a strong indicator of the atherogenic potential of plasma.

AIP correlates significantly with the size of LDL particles. A high AIP value is associated with a predominance of small, dense LDL particles, which are highly atherogenic and increase the risk of plaque formation in arteries.

Why is AIP a Powerful Marker?

• It reflects the balance between atherogenic (risk-promoting) and anti-atherogenic (protective) lipoproteins.
• It is a better predictor of heart disease risk than individual lipid markers, especially in patients with normal LDL-C levels.
• A high AIP is a strong, independent risk factor for atherosclerosis and coronary heart disease.

Interpreting the Result

Managing Your Atherogenic Risk

A high AIP indicates an unfavorable lipid profile. Improving this index involves strategies to lower triglycerides and/or raise HDL cholesterol.

• Reduce intake of sugars and refined carbohydrates, which are major drivers of high triglycerides.
• Increase intake of omega-3 fatty acids found in fatty fish, flaxseeds, and walnuts.
• Engage in regular aerobic exercise, which is proven to raise HDL levels.
• Maintain a healthy weight and limit alcohol consumption.
• Consult your doctor for a comprehensive management plan.