SPINA-GT Calculator

What is SPINA-GT?

SPINA-GT is a calculated index that estimates the maximum secretion capacity of the thyroid gland for thyroxine (T4) in picomoles per second (pmol/s). It is derived from a mathematical model of thyroid homeostasis using fasting TSH and FT4 levels.

Unlike measuring hormone levels directly, SPINA-GT provides a dynamic perspective on the thyroid's functional ability, which can be altered in various thyroid disorders even before hormone levels fall outside the reference range.

Why is SPINA-GT a Useful Indicator?

• Provides insight into the functional reserve of the thyroid gland.
• Can help in the early detection of thyroid dysfunction, such as subclinical hypothyroidism.
• Useful in research and clinical settings to understand the complex regulation of the thyroid axis.

Interpreting the Result (Reference Guide)

Clinical Significance

The interpretation of SPINA-GT should always be done in conjunction with the overall clinical picture of the patient.

• A low SPINA-GT may indicate reduced thyroid capacity, as seen in primary hypothyroidism or after thyroid surgery.
• A high SPINA-GT can be observed in conditions with thyroid autonomy, like Graves' disease or toxic nodules.
• This index is a sophisticated tool for understanding thyroid physiology.
• Consultation with an endocrinologist is essential for diagnosis and management.