Mentzer Index Calculator

Differentiating between Iron Deficiency Anemia and Thalassemia Trait

Last updated on: June 21, 2025

Mentzer Index Calculator

fL
x10⁶/μL

What is the Mentzer Index?

The Mentzer Index is a simple calculation derived from a complete blood count (CBC). It is used as a screening tool to help distinguish between two common causes of microcytic anemia: iron deficiency anemia and beta-thalassemia trait.

The index is calculated by dividing the Mean Corpuscular Volume (MCV) by the Red Blood Cell (RBC) count. Its simplicity makes it a useful first step in hematological diagnosis.

Why is it Important?

  • Provides a quick, cost-effective clue for the differential diagnosis of microcytic anemia.
  • Can help guide further diagnostic testing, such as iron studies or hemoglobin electrophoresis.
  • Reduces the likelihood of misdiagnosis and helps in initiating the correct patient management pathway.

Interpreting Your Result (Reference Guide)

Index > 13: A value greater than 13 is suggestive of Iron Deficiency Anemia.
Index < 13: A value less than 13 is suggestive of Beta-Thalassemia Trait.

Understanding Anemia

This index is a guide and not a definitive diagnosis. The final diagnosis of anemia and its cause requires a comprehensive evaluation by a healthcare professional, including a full medical history and additional laboratory tests.

  • Iron Deficiency Anemia: Often treated with iron supplementation and dietary changes.
  • Thalassemia Trait: A genetic condition that usually does not require treatment, but genetic counseling may be recommended.
  • Consultation is Key: Never self-diagnose or self-treat based on this or any other single lab value.
  • Further Tests: Your doctor may order tests for serum ferritin, transferrin, or HbA2 levels.

This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.