APRI Score Calculator
A non-invasive marker for assessing liver fibrosis
Last updated on: July 6, 2025
APRI Score Calculator
What is the APRI Score?
The APRI (AST to Platelet Ratio Index) is a simple, non-invasive scoring system used to estimate the degree of liver fibrosis in patients with chronic liver disease, most notably chronic hepatitis C.
It uses two standard laboratory tests: the AST level and the platelet count. A higher score correlates with a greater likelihood of significant fibrosis or cirrhosis.
Why is it a Useful Index?
- Provides a cost-effective alternative to liver biopsy, which is an invasive and expensive procedure.
- Helps in identifying patients at low risk for significant fibrosis, potentially avoiding the need for a biopsy.
- Can be used to monitor the progression of liver disease over time.
Interpreting the Result (Common Cutoffs)
APRI Score < 0.5:
Low likelihood of significant liver fibrosis (F0-F1).
APRI Score 0.5 - 1.5:
Indeterminate result. The presence of significant fibrosis cannot be reliably ruled in or out.
APRI Score > 1.5:
High likelihood of significant liver fibrosis (≥F2). Suggests a high probability of cirrhosis if score is >2.0.
Clinical Context and Management
- A low score has a high negative predictive value, meaning it is good at ruling out significant fibrosis.
- A high score has a moderate positive predictive value, suggesting that significant fibrosis is likely, and often warrants further investigation.
- Other non-invasive tests (like FibroScan® or other fibrosis markers) may be used for confirmation.
- Treatment is aimed at the underlying cause of the liver disease.
This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.