GPR (GGT-to-Platelet Ratio) Calculator
A valuable tool for predicting significant fibrosis in chronic liver disease
Last updated on: July 11, 2025
GPR Calculator
What is the GGT-to-Platelet Ratio (GPR)?
The GGT-to-Platelet Ratio (GPR) is a simple, non-invasive index calculated from Gamma-Glutamyl Transferase (GGT) and platelet count. It was developed as a marker to predict the presence of significant liver fibrosis and cirrhosis.
It has shown particularly high accuracy in patients with chronic hepatitis B (CHB), sometimes outperforming other common indices like APRI and FIB-4 in this specific population.
Why is the GPR Useful?
- High diagnostic accuracy for significant fibrosis in chronic hepatitis B patients.
- Uses simple and universally available laboratory tests.
- Can help reduce the number of liver biopsies needed for staging liver disease.
Interpreting the Result (Reference Guide)
Clinical Context
Like other non-invasive markers, the GPR should be used as a guide and interpreted within the complete clinical context of the patient.
- A low GPR score (<0.5) has a strong negative predictive value, reliably ruling out significant fibrosis.
- A high GPR score (≥0.5) indicates a high likelihood of significant fibrosis, warranting further investigation.
- Alcohol consumption can significantly elevate GGT levels, which should be taken into account.
- Always consult a specialist for a comprehensive diagnosis and treatment plan.
This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.