Martin-Hopkins LDL-C Calculator
An advanced method for a more accurate LDL-C estimation
Last updated on: July 1, 2025
Martin-Hopkins Calculation
What is the Martin-Hopkins Formula?
The Martin-Hopkins formula is a novel method for calculating LDL-Cholesterol (LDL-C) that improves accuracy by using an adjustable factor for estimating VLDL cholesterol based on triglyceride and non-HDL cholesterol levels.
This dynamic approach better estimates VLDL-C across a wide range of triglyceride values, making it especially useful for patients with high triglycerides.
Note: The adjustable factor (D) is automatically determined by the calculator based on your values.
Why is it More Accurate?
- It avoids the underestimation of LDL-C that often occurs with the Friedewald formula, especially when triglycerides are high.
- Provides a more reliable risk assessment for cardiovascular disease.
- Reduces the need for expensive direct LDL-C measurements in most cases.
Interpreting Your LDL-C Result
Below 55 mg/dL:
Recommended target for patients with very high cardiovascular risk (e.g., established cardiovascular disease, recent heart attack or stroke).
55–69 mg/dL:
Target for high-risk individuals (e.g., diabetes with organ damage, severe chronic kidney disease, or multiple major risk factors).
70–99 mg/dL:
Optimal for most high-risk adults.
100–129 mg/dL:
Near optimal/above optimal (acceptable for moderate risk).
130–159 mg/dL:
Borderline high – lifestyle changes are recommended.
160–189 mg/dL:
High – consider additional therapy.
190 mg/dL and above:
Very high – needs urgent medical evaluation and intervention.
This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.