LDL-C by Sampson Equation
More accurate LDL estimate at higher triglycerides
Last updated on: October 9, 2025
Enter values
What is the Sampson equation?
The Sampson equation estimates LDL-C using TC, HDL-C, and TG with correction terms that improve accuracy when TG is elevated.
It outperforms the Friedewald formula when TG is 200–800 mg/dL and does not require direct VLDL measurement.
Limits of use
- Valid up to TG = 800 mg/dL (8 g/L).
- Inputs may be entered in mg/dL, mmol/L, or g/L. Conversions are handled automatically.
- Not intended for severe chylomicronemia or rare dyslipidemias without laboratory confirmation.
Interpretation
Optimal:
LDL < 100 mg/dL. Maintain healthy lifestyle and periodic monitoring.
Near optimal:
100–129 mg/dL. Consider lifestyle optimization and risk-based targets.
Borderline high:
130–159 mg/dL. Review risk profile; therapy may be indicated.
High:
160–189 mg/dL. Pharmacologic therapy is often recommended.
Very high:
≥190 mg/dL. Intensive therapy and evaluation for familial hypercholesterolemia.
This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.