eGDR Calculator

Estimate glucose disposal rate (eGDR) using a waist circumference-based formula as a practical surrogate marker of insulin resistance.

Last updated on: March 30, 2026

Calculate eGDR

%
Enter HbA1c as a percentage.
Enter waist circumference in cm or inches. The result will automatically show both units.
Select yes if hypertension is present. In many studies, this includes diagnosis, antihypertensive treatment, or blood pressure above threshold.

Clinical Significance

Estimated glucose disposal rate (eGDR) is a practical surrogate marker of insulin sensitivity. Lower eGDR values generally indicate greater insulin resistance.

It has been widely studied in type 1 diabetes and increasingly in broader metabolic and cardiovascular research as a useful risk-associated marker.

Formula and Example

This calculator uses the waist circumference-based eGDR equation: eGDR = 21.158 − (0.09 × waist in cm) − (3.407 × hypertension) − (0.551 × HbA1c).

This formula is practical because it uses easily available clinical inputs and is widely used in recent studies of metabolic and cardiovascular risk.

Example: HbA1c 7.0%, waist circumference 90 cm, and no hypertension gives an eGDR of about 9.40 mg/kg/min.

Reference Interpretation

Very Low eGDR: Below 4.0 mg/kg/min. This suggests marked insulin resistance and may be associated with higher metabolic and cardiovascular risk.
Low eGDR: From 4.0 to 5.9 mg/kg/min. This suggests reduced insulin sensitivity and should be interpreted with the broader metabolic context.
Intermediate eGDR: From 6.0 to 7.9 mg/kg/min. This is an intermediate range and should be read alongside other cardiometabolic markers.
Higher eGDR: 8.0 mg/kg/min or higher. This generally suggests relatively better insulin sensitivity compared with lower eGDR values.

Clinical Notes

eGDR is a surrogate marker rather than a direct physiological measurement. It is most useful when interpreted together with the broader clinical and cardiometabolic picture.

  • Lower eGDR generally indicates greater insulin resistance.
  • This calculator uses the waist circumference-based formula, which is practical and widely used in recent studies.
  • Interpret together with HbA1c, blood pressure, adiposity, and other cardiometabolic markers.
  • eGDR is useful for risk stratification and interpretation, but not as a stand-alone diagnosis.

This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.

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