PESI Score Calculator

Calculate the Pulmonary Embolism Severity Index (PESI score calculator) for pulmonary embolism risk stratification, PESI score interpretation, and guideline-based clinical context.

Last updated on: April 16, 2026

Calculate PESI Score

years
Age contributes directly to the original PESI score as age in years.
Male sex adds 10 points in the original PESI score.
Select yes if pulse is 110/min or higher.
Select yes if systolic blood pressure is below 100 mmHg.
Select yes if respiratory rate is 30/min or higher.
Select yes if temperature is below 36°C or below 96.8°F.
Select yes if oxygen saturation is below 90%.

PESI Score Interpretation

The Pulmonary Embolism Severity Index (PESI score calculator) estimates short-term mortality risk in patients with confirmed acute pulmonary embolism using 11 bedside clinical variables.

It is most useful for PESI score interpretation and for identifying lower-risk patients, especially classes I and II, who may be candidates for less intensive management in the appropriate clinical context.

Risk Classes and Interpretation

Class I - Very Low Risk: Score ≤ 65. Very low 30-day mortality risk, approximately 0–1.6%.
Class II - Low Risk: Score 66–85. Low 30-day mortality risk, approximately 1.7–3.5%.
Class III - Intermediate Risk Category: Score 86–105. Intermediate 30-day mortality risk, approximately 3.2–7.1%.
Class IV - High Risk: Score 106–125. High 30-day mortality risk, approximately 4.0–11.4%.
Class V - Very High Risk: Score > 125. Very high 30-day mortality risk, approximately 10.0–24.5%.

PESI Score Guidelines Context

PESI score guidelines context matters: PESI or sPESI is commonly used after diagnosis of acute PE to help define low-risk versus non-low-risk patients.

However, guideline-based risk stratification does not rely on PESI alone. Hemodynamic instability, right ventricular dysfunction, and cardiac biomarkers remain important in the full risk assessment.

PESI Score Intermediate Risk

PESI score intermediate risk is often discussed around class III, but this should not be confused with formal intermediate-low or intermediate-high risk classification in guideline algorithms.

In practice, patients with higher PESI classes may still need further assessment with imaging and biomarkers to clarify true intermediate-low versus intermediate-high risk.

This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.

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