sPESI Calculator

Calculate the Simplified Pulmonary Embolism Severity Index (sPESI) to identify low-risk versus higher-risk patients with acute pulmonary embolism.

Last updated on: April 1, 2026

Calculate sPESI

Select yes if age is over 80 years.
Select yes if there is a history of cancer.
Select yes if chronic cardiopulmonary disease is present.
Select yes if heart rate is 110 bpm or higher.
Select yes if systolic blood pressure is below 100 mmHg.
Select yes if oxygen saturation is below 90%.

What sPESI Measures

The Simplified Pulmonary Embolism Severity Index (sPESI) is a bedside risk score for acute pulmonary embolism. It uses six binary variables, each worth one point.

Its main clinical role is to help identify patients at low risk when the total score is 0, versus patients at higher risk when the score is 1 or more.

Risk Groups and Interpretation

Low-Risk Profile: Score 0. This supports a low-risk profile within validated prognostic models and may help identify candidates for less intensive management in the appropriate clinical setting.
Higher-Risk Profile: Score 1 or higher. This indicates a higher-risk profile compared with score 0 and supports closer assessment, broader risk stratification, and management planning.

Guideline Context

sPESI is used as a practical simplified prognostic tool in acute pulmonary embolism and is commonly discussed alongside PESI in modern risk stratification pathways.

A low-risk classification with sPESI does not replace clinical judgment. Right ventricular dysfunction, biomarker results, and hemodynamic status remain important.

Practical Workflow

A score of 0 may support a low-risk pathway in carefully selected patients after full assessment.

A score of 1 or more supports higher-risk categorization and usually justifies more cautious monitoring and broader evaluation.

This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.

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