CORE Liver Risk Calculator
Estimate the 10-year risk of liver cirrhosis or related complications using age, sex and routine liver enzymes.
Last updated on: June 5, 2026
Calculate CORE Liver Risk
What is the CORE Liver Risk Calculator?
CORE stands for Cirrhosis Outcome Risk Estimator. It is a prediction model designed to estimate the 10-year probability of liver cirrhosis or related major liver complications in people from the general population with no known liver disease.
The model uses five routinely available variables: age, sex, GGT, AST and ALT. It should be interpreted as an aid to clinical assessment, not as a diagnosis.
Required inputs
- Age in years.
- Sex: male or female.
- GGT, AST and ALT values, either in U/L or µkat/L.
- The calculator converts U/L to µkat/L internally before applying the CORE model.
How to interpret the result
Lower estimated risk:
The estimated 10-year risk is below 1%. Interpret together with clinical context, liver enzyme pattern and patient risk factors.
Intermediate estimated risk:
The estimated 10-year risk is between 1% and 10%. Consider clinical review and evaluation of reversible causes of abnormal liver enzymes.
Higher estimated risk:
The estimated 10-year risk is 10% or higher. This does not diagnose cirrhosis, but it supports further clinical evaluation.
Important limitations
CORE is a risk prediction tool and should not replace medical judgment.
- It is intended for people without known liver disease.
- Recent exercise, alcohol intake, acute illness and medication effects may alter liver enzyme values.
- The result is not a diagnosis of cirrhosis.
- This local implementation does not display the official prediction interval.
This page has been medically reviewed by Dr. Khoulah Attia – PharmD, Immunology Specialist.